A clinically feasible circulating tumor cell sorting system for monitoring the progression of advanced hepatocellular carcinoma.

ABSTRACT:

Background

Hematogenous metastasis is essential for the progression of advanced hepatocellular carcinoma (HCC) and can occur even after patients receive multidisciplinary therapies, including immunotherapy and hepatectomy; circulating tumor cells (CTCs) are one of the dominant components of the metastatic cascade. However, the CTC capture efficiency for HCC is low due to the low sensitivity of the detection method. In this study, epithelial cell adhesion molecule (EpCAM)/vimentin/Glypican-3 (GPC3) antibody-modified lipid magnetic spheres (LMS) were used to capture tumor cells with epithelial phenotype, mesenchymal phenotype and GPC3 phenotype, respectively, in order to capture more CTCs with a more comprehensive phenotype for monitoring tumor metastasis.

Results

The novel CT

SUBMITTER: Huang XY 

PROVIDER: S-EPMC9867854 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature