Pab1 acetylation at K131 decreases stress granule formation in Saccharomyces cerevisiae.

ABSTRACT: Under environmental stress, such as glucose deprivation, cells form stress granules-the accumulation of cytoplasmic aggregates of repressed translational initiation complexes, proteins, and stalled mRNAs. Recent research implicates stress granules in various diseases, such as neurodegenerative diseases, but the exact regulators responsible for the assembly and disassembly of stress granules are unknown. An important aspect of stress granule formation is the presence of posttranslational modifications on core proteins. One of those modifications is lysine acetylation, which is regulated by either a lysine acetyltransferase or a lysine deacetylase enzyme. This work deciphers the impact of lysine acetylation on an essential protein found in Saccharomyces cerevisiae stress granules, poly(A)-bi

SUBMITTER: Sivananthan S 

PROVIDER: S-EPMC9867979 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature