Development and validation of circulating protein signatures as diagnostic biomarkers for biliary tract cancer.

ABSTRACT:

Background & aims

Biliary tract cancer (BTC) is associated with a dismal prognosis, partly because it is typically diagnosed late, highlighting the need for diagnostic biomarkers. The purpose of this project was to identify and validate multiprotein signatures that could differentiate patients with BTC from non-cancer controls.

Methods

In this study, we included treatment-naïve patients with BTC, healthy controls, and patients with benign conditions including benign biliary tract disease. Participants were divided into three non-overlapping cohorts: a case-control-based discovery cohort (BTC = 186, controls = 249); a case-control-based validation cohort (validation cohort 1: BTC = 113, controls = 241); and a cohort study-based validation cohort including participants (BTC =

SUBMITTER: Christensen TD 

PROVIDER: S-EPMC9867981 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature