Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort.

ABSTRACT:

Rationale & objective

Donor acute kidney injury (AKI) activates innate immunity, enhances HLA expression in the kidney allograft, and provokes recipient alloimmune responses. We hypothesized that injury and inflammation that manifested in deceased-donor urine biomarkers would be associated with higher rates of biopsy-proven acute rejection (BPAR) and allograft failure after transplantation.

Study design

Prospective cohort.

Setting & participants

862 deceased donors for 1,137 kidney recipients at 13 centers.

Exposures

We measured concentrations of interleukin 18 (IL-18), kidney injury molecule 1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) in deceased donor urine. We also used the Acute Kidney Injury Network (AKIN) criteria to assess donor clin

SUBMITTER: Reese PP 

PROVIDER: S-EPMC9868058 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature