Computational framework for the techno-economic analysis of monoclonal antibody capture chromatography platforms.

ABSTRACT: We developed a computational framework that integrates commercial software components to perform customizable technoeconomic feasibility analyses. The use of multiple software packages overcomes the shortcomings of each to provide a detailed simulation that can be used for sensitivity analyses and optimizations. In this paper, the framework was used to evaluate the performance of monoclonal antibody capture processes. To this end, the simulation framework incorporated dynamic models for the affinity chromatography step that were validated with experimental breakthrough curves. The results were integrated with an Intelligen SuperPro Designer process simulation for the evaluation of key performance indicators of the operations. As proof of concept, the framework was used to perform a sensiti

SUBMITTER: Romero JJ 

PROVIDER: S-EPMC9868085 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature