Intratumoral STING activation causes durable immunogenic tumor eradication in the KP soft tissue sarcoma model.

ABSTRACT:

Introduction

Soft tissue sarcomas (STS) are highly metastatic, connective-tissue lineage solid cancers. Immunologically, sarcomas are frequently characterized by a paucity of tumor infiltrating lymphocytes and an immune suppressive microenvironment. Activation of the STING pathway can induce potent immune-driven anti-tumor responses within immunogenic solid tumors; however, this strategy has not been evaluated in immunologically cold sarcomas. Herein, we assessed the therapeutic response of intratumoral STING activation in an immunologically cold murine model of undifferentiated pleomorphic sarcoma (UPS).

Materials and results

A single intratumoral injection of the murine STING agonist, DMXAA resulted in durable cure in up to 60% of UPS-bearing mice. In mice with synchronous

SUBMITTER: Marritt KL 

PROVIDER: S-EPMC9868147 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature