Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling.

ABSTRACT:

Background

Type 1 diabetes mellitus (T1DM) and periodontitis have long been thought to be biologically connected. Indeed, T1DM is a risk factor for periodontal disease. With the population of diabetic individuals growing, it is more important than ever to understand the negative consequences of diabetes on the periodontium and the mechanisms. The aim of this study was to find out the early effects of T1DM on the periodontium without any experimentally induced periodontitis.

Methods

We established the streptozotocin (STZ)-induced diabetic mouse model and examined the periodontium 8 weeks later by histology, molecular and cellular assays. Microcomputed tomographic (𝜇CT) imaging and in vivo fluorochrome labeling were also used to quantify bone volume and mineral apposition rat

SUBMITTER: Yuan X 

PROVIDER: S-EPMC9868190 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature