The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine model.

ABSTRACT:

Objectives

This study attempted to explore the hemodynamics and potential mechanisms driving pulmonary circulation in status of ventricular fibrillation (VF) following continuous-flow left ventricular assist device (CF-LVAD) implantation.

Methods

An ovine CF-LVAD model was built in small-tailed Han sheep, with the pump speed set as 2,400 rpm. VF was induced following ventricular tachycardia using a temporary pacemaker probe to stimulate the right and left ventricular free walls. The central venous pressure (CVP), pump flow (PF), pulmonary artery flow (PAF) and other major indicators were observed and recorded after VF.

Results

Low-flow systemic and pulmonary circulation could be sustained for 60 min under VF with sinus atrial rhythm after CF-LVAD implantation. The CVP

SUBMITTER: Yu XY 

PROVIDER: S-EPMC9868250 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature