All-optical observation on activity-dependent nanoscale dynamics of myelinated axons.

ABSTRACT:

Significance

In the mammalian brain, rapid conduction of neural information is supported by the myelin, the functional efficacy of which shows steep dependence on its nanoscale cytoarchitecture. Although previous in vitro studies have suggested that neural activity accompanies nanometer-scale cellular deformations, whether neural activity can dynamically remodel the myelinated axon has remained unexplored due to the technical challenge in observing its nanostructural dynamics in living tissues.

Aim

We aim to observe activity-dependent nanostructural dynamics of myelinated axons in a living brain tissue.

Approach

We introduced a novel all-optical approach combining a nanoscale dynamic readout based on spectral interferometry and optogenetic control of neural exc

SUBMITTER: Kwon J 

PROVIDER: S-EPMC9868287 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature