Comparative plasma and urine metabolomics analysis of juvenile and adult canines.

ABSTRACT:

Background and aims

The metabolomic profile of a biofluid can be affected by age, and thus provides detailed information about the metabolic alterations in biological processes and reflects the in trinsic rule regulating the growth and developmental processes.

Methods

To systemically investigate the characteristics of multiple metabolic profiles associated with canine growth, we analyzed the metabolomics in the plasma and urine samples from 15 young and 15 adult beagle dogs via UHPLC-Q-TOFMS-based metabolomics. Blood routine and serum biochemical analyses were also performed on fasting blood samples.

Results

The metabolomics results showed remarkable differences in metabolite fingerprints both in plasma and urine between the young and adult groups. The most obvious ag

SUBMITTER: Wu T 

PROVIDER: S-EPMC9868312 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature