Using metabolic potential within the airway microbiome as predictors of clinical state in persons with cystic fibrosis.

ABSTRACT:

Introduction

Pulmonary exacerbations (PEx) in persons with cystic fibrosis (CF) are primarily related to acute or chronic inflammation associated with bacterial lung infections, which may be caused by several bacteria that activate similar bacterial genes and produce similar by-products. The goal of our study was to perform a stratified functional analysis of bacterial genes at three distinct time points in the treatment of a PEx in order to determine the role that specific airway microbiome community members may play within each clinical state (i.e., PEx, end of antibiotic treatment, and follow-up). Our secondary goal was to compare the change between clinical states with the metabolic activity of specific airway microbiome community members.

Methods

This was a prospective

SUBMITTER: Shumyatsky G 

PROVIDER: S-EPMC9868313 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature