Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development.

ABSTRACT: Neural tube closure is a fundamental process during vertebrate embryogenesis, which leads to the formation of the central nervous system. Defective neural tube closure leads to neural tube defects which are some of the most common human birth defects. While the intrinsic morphogenetic events shaping the neuroepithelium have been studied extensively, how tissues mechanically coupled with the neural plate influence neural tube closure remains poorly understood. Here, using Xenopus laevis embryos, live imaging in combination with loss of function experiments and morphometric analysis of fixed samples we explore the reciprocal mechanical communication between the neural plate and the somitic mesoderm and its impact on tissue morphogenesis. We show that although somitic mesoderm converge

SUBMITTER: Christodoulou N 

PROVIDER: S-EPMC9868421 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature