Identification of biomarkers related to copper metabolism in patients with pulmonary arterial hypertension.

ABSTRACT:

Background

The pathogenesis of pulmonary arterial hypertension (PAH) and associated biomarkers remain to be studied. Copper metabolism is an emerging metabolic research direction in many diseases, but its role in PAH is still unclear.

Methods

PAH-related datasets were downloaded from the Gene Expression Omnibus database, and 2067 copper metabolism-related genes (CMGs) were obtained from the GeneCards database. Differential expression analysis and the Venn algorithm were used to acquire the differentially expressed CMGs (DE-CMGs). DE-CMGs were then used for the coexpression network construction to screen candidate key genes associated with PAH. Furthermore, the predictive performance of the model was verified by receiver operating characteristic (ROC) analysis, and genes with

SUBMITTER: Wang L 

PROVIDER: S-EPMC9868507 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature