Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8⁺ T and NK cells.

ABSTRACT: Cannabinoid (CB) receptors (CB₁ and CB₂) are expressed on cancer cells and their expression influences carcinogenesis in various tumor entities. Cells of the tumor microenvironment (TME) also express CB receptors, however, their role in tumor development is still unclear. We, therefore, investigated the role of TME-derived CB₁ and CB₂ receptors in a model of non-small cell lung cancer (NSCLC). Leukocytes in the TME of mouse and human NSCLC express CB receptors, with CB₂ showing higher expression than CB₁. In the tumor model, using CB₁- (CB₁ ^-/-) and CB₂-knockout (CB₂ ^-/-) mice, only deficiency of CB₂, but not of CB₁, resulted in reduction

SUBMITTER: Sarsembayeva A 

PROVIDER: S-EPMC9868666 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature