The significant clinical correlation of the intratumor oral microbiome in oral squamous cell carcinoma based on tissue-derived sequencing.

ABSTRACT: Background: The microbiota is a critical component of the complex human microenvironment, impacting various physiological processes and disease development via the microbe-host interaction. In particular, the oral microbiota profoundly affects tumor development and progression. There is increasing evidence that oral microbiota is associated with the development of oral cancer, especially oral squamous cell carcinoma (OSCC). Methods: We comprehensively analyzed the oral microbiota in 133 OSCC samples worldwide. Subsequently, we evaluated the microbial compositions between OSCC patients and healthy people and their correlation with clinical parameters. The value of the oral microbiota as a diagnostic and prognostic biomarker was also determined. Results: This stud

SUBMITTER: Li Z 

PROVIDER: S-EPMC9868672 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature