Dietary supplement of mushrooms promotes SCFA production and moderately associates with IgA production: A pilot clinical study.

ABSTRACT:

Background

Mushrooms are rich in dietary fiber, and fiber intake has been reported to increase the levels of short-chain fatty acids (SCFAs). It has also been reported that SCFAs promote immunoglobulin A (IgA) production, indicating involvement in systemic immunity.

Objectives

The objective of this study was to evaluate the effects of mushroom consumption on the amount of intestinal IgA. We also aimed to comprehensively evaluate the gut microbiota and intestinal metabolome and to conduct an exploratory analysis of their relationship with IgA.

Methods

Healthy adults (n = 80) were enrolled in a parallel group trial. Participants consumed a diet with mushrooms or a placebo diet once daily for 4 weeks. Gut microbiota profiles were assessed by sequencing the bacteri

SUBMITTER: Nishimoto Y 

PROVIDER: S-EPMC9868702 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature