SENP3 promotes tumor progression and is a novel prognostic biomarker in triple-negative breast cancer.

ABSTRACT:

Background

The clinical outcome of triple-negative breast cancer (TNBC) is poor. Finding more targets for the treatment of TNBC is an urgent need. SENPs are SUMO-specific proteins that play an important role in SUMO modification. Among several tumor types, SENPs have been identified as relevant biomarkers for progression and prognosis. The role of SENPs in TNBC is not yet clear.

Methods

The expression and prognosis of SENPs in TNBC were analyzed by TCGA and GEO data. SENP3 coexpression regulatory networks were determined by weighted gene coexpression network analysis (WGCNA). Least absolute shrinkage and selection operator (LASSO) and Cox univariate analyses were used to develop a risk signature based on genes associated with SENP3. A time-dependent receiver operating charac

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC9868814 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature