Inhibitory and excitatory responses in the dorso-medial prefrontal cortex during threat processing.

ABSTRACT:

Objective

To evaluate cortical excitability during instructed threat processing.

Methods

Single and paired transcranial magnetic stimulation (TMS) pulses were applied to the right dorsomedial prefrontal cortex (dmPFC) during high-density electroencephalography (EEG) recording in young healthy participants (n = 17) performing an instructed threat paradigm in which one of two conditioned stimuli (CS+ but not CS-) was paired with an electric shock (unconditioned stimulus [US]). We assessed TMS-induced EEG responses with spectral power (both at electrode and source level) and information flow (effective connectivity) using Time-resolved Partial Directed Coherence (TPDC). Support vector regression (SVR) was used to predict behavioral fear ratings for CS+ based on TMS impac

SUBMITTER: Chirumamilla VC 

PROVIDER: S-EPMC9868831 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature