Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics.

ABSTRACT: Neurological motor disorders (NMDs) such as Parkinson's disease and Huntington's disease are characterized by the accumulation and aggregation of misfolded proteins that trigger cell death of specific neuronal populations in the central nervous system. Differential neuronal loss initiates the impaired motor control and cognitive function in the affected patients. Although major advances have been carried out to understand the molecular basis of these diseases, to date there are no treatments that can prevent, cure, or significantly delay the progression of the disease. In this context, strategies such as gene editing, cellular therapy, among others, have gained attention as they effectively reduce the load of toxic protein aggregates in different models of neurodegeneration. Nevertheless,

SUBMITTER: Perez-Arancibia R 

PROVIDER: S-EPMC9868863 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature