Diagnostic value of [⁶⁸Ga]Ga-FAPI-04 in patients with colorectal cancer in comparison with [¹⁸F]F-FDG PET/CT.

ABSTRACT:

Purpose

This study aimed to compare the diagnostic performance of [⁶⁸Ga]Ga-FAPI-04 PET/CT and [¹⁸F]F-FDG PET/CT in primary and metastatic colorectal cancer (CRC) lesions.

Methods

This single-center preliminary clinical study (NCT04750772) was conducted at the Peking University Cancer Hospital & Institute and included 61 participants with CRC who underwent sequential evaluation through PET/CT with [¹⁸F]F-FDG and [⁶⁸Ga]Ga-FAPI-04. Their PET/CT images were analysed to quantify the uptake of the two tracers in the form of maximum standardised uptake (SUV_max) values and target-to-background ratio (TBR), which were then compared using Wilcoxon's signed-rank test. The final changes in the tumour-node-metastasis (TNM) stage of a

SUBMITTER: Lin X 

PROVIDER: S-EPMC9869033 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature