Increased functional connectivity patterns in mild Alzheimer's disease: A rsfMRI study.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. In view of our rapidly aging population, there is an urgent need to identify Alzheimer's disease (AD) at an early stage. A potential way to do so is by assessing the functional connectivity (FC), i.e., the statistical dependency between two or more brain regions, through novel analysis techniques.

Methods

In the present study, we assessed the static and dynamic FC using different approaches. A resting state (rs)fMRI dataset from the Alzheimer's disease neuroimaging initiative (ADNI) was used (n = 128). The blood-oxygen-level-dependent (BOLD) signals from 116 regions of 4 groups of participants, i.e., healthy controls (HC; n = 35), early mild cognitive impairment (EMCI

SUBMITTER: Penalba-Sanchez L 

PROVIDER: S-EPMC9869068 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature