Potential dynamic regional brain biomarkers for early discrimination of autism and language development delay in toddlers.

ABSTRACT:

Background

The early diagnosis of autism in children is particularly important. However, there is no obvious objective indices for the diagnosis of autism spectrum disorder (ASD), especially in toddlers aged 1-3 years with language development delay (LDD). The early differential diagnosis of ASD is challenging.

Objective

To examine differences in the dynamic characteristics of regional neural activity in toddlers with ASD and LDD, and whether the differences can be used as an imaging biomarker for the early differential diagnosis of ASD and LDD.

Methods

Dynamic regional homogeneity (dReHo) and dynamic amplitude of low-frequency fluctuations (dALFF) in 55 children with ASD and 31 with LDD, aged 1-3 years, were compared. The correlations between ASD symptoms and the val

SUBMITTER: Wu S 

PROVIDER: S-EPMC9869111 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature