The expression pattern of GDF15 in human brain changes during aging and in Alzheimer's disease.

ABSTRACT:

Introduction

Growth Differentiation Factor 15 (GDF15) is a mitochondrial-stress-responsive molecule whose expression strongly increases with aging and age-related diseases. However, its role in neurodegenerative diseases, including Alzheimer's disease (AD), is still debated.

Methods

We have characterized the expression of GDF15 in brain samples from AD patients and non-demented subjects (controls) of different ages.

Results

Although no difference in CSF levels of GDF15 was found between AD patients and controls, GDF15 was expressed in different brain areas and seems to be predominantly localized in neurons. The ratio between its mature and precursor form was higher in the frontal cortex of AD patients compared to age-matched controls (p < 0.05). Moreover, this

SUBMITTER: Chiariello A 

PROVIDER: S-EPMC9869280 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature