Rb deficiency, neuronal survival and neurodegeneration: In search of the perfect mouse model.

ABSTRACT: Three decades following the introduction of the first Rb knockout (KO) mouse model, the role of this critical protein in regulating brain development during embryogenesis and beyond remains a major scientific interest. Rb is a tumor suppressor gene known as the master regulator of the G1/S checkpoint and control of cell cycle progression in stem and progenitor cells, but also their differentiated progeny. Here, we review the recent literature about the various Rb conditional Knockout (cKO) and inducible Knockout (iKO) models studied thus far, highlighting how findings should always be interpreted in light of the model and context under inquiry especially when studying the role of Rb in neuronal survival. There is indeed evidence of age-specific, cell type-specific and region-specific effec

SUBMITTER: Omais S 

PROVIDER: S-EPMC9869410 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature