High intratumoral CD8⁺ T-cell infiltration is associated with improved survival in prostate cancer patients undergoing radical prostatectomy.

ABSTRACT:

Background

A high density of CD8⁺ tumor infiltrating lymphocytes (TILs) is associated with improved survival in multiple cancers, but its prognostic role in prostate cancer remains controversial. The aim of our study was to evaluate the prognostic value of CD8⁺ TILs in prostate cancer patients undergoing radical prostatectomy (RP). We hypothesized that elevated density of CD8⁺ TILs in the RP specimen would correlate with improved clinical outcomes. This information may be helpful for future immunotherapy clinical trial design and treatment selection.

Methods

Tumor microarrays constructed from 230 patients with localized prostate cancers who underwent RP from 2006 to 2012 at Roswell Park Comprehensive Cancer Center were analyzed retrospectivel

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9869431 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature