The density of bone marrow mononuclear cells and CD34+ cells in patients with three neurologic conditions.

ABSTRACT:

Background

This study aimed to identify the density of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of patients with three neurologic conditions.

Methods

The study included 88 patients with three neurologic conditions: 40 with cerebral palsy (CP) due to oxygen deprivation (OD), 23 with CP related to neonatal icterus (NI), and 25 with neurological sequelae after traumatic brain injury. Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater. MNCs were isolated by Ficoll gradient centrifugation and then infused intrathecally.

Results

There was a significant difference in the average MNC per ml and percentage of CD34+ cells by the type of disease, age group, and infusion time (

SUBMITTER: Nguyen KT 

PROVIDER: S-EPMC9869514 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature