Parkin coregulates glutathione metabolism in adult mammalian brain.

ABSTRACT: We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn with Sod2 haploinsufficiency in mice. Although adult prkn^-/-//Sod2^± animals did not develop dopamine cell loss in the S. nigra, they had more reactive oxidative species and a higher concentration of carbonylated proteins in the brain; bi-genic mice also showed a trend for more nitrotyrosinated proteins. Because these redox changes were seen in the cytosol rather than mitochondria, we next explored the thiol network in the context of PRKN expression. We detected a parkin deficiency-associated increase in the ratio of reduced glutath

SUBMITTER: El Kodsi DN 

PROVIDER: S-EPMC9869535 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature