Early peripheral blood gene expression associated with good and poor 90-day ischemic stroke outcomes.

ABSTRACT:

Background

This study identified early immune gene responses in peripheral blood associated with 90-day ischemic stroke (IS) outcomes.

Methods

Peripheral blood samples from the CLEAR trial IS patients at ≤ 3 h, 5 h, and 24 h after stroke were compared to vascular risk factor matched controls. Whole-transcriptome analyses identified genes and networks associated with 90-day IS outcome assessed using the modified Rankin Scale (mRS) and the NIH Stroke Scale (NIHSS).

Results

The expression of 467, 526, and 571 genes measured at ≤ 3, 5 and 24 h after IS, respectively, were associated with poor 90-day mRS outcome (mRS ≥ 3), while 49, 100 and 35 genes at ≤ 3, 5 and 24 h after IS were associated with good mRS 90-day outcome (mRS ≤ 2). Poor outcomes were associated with up-reg

SUBMITTER: Amini H 

PROVIDER: S-EPMC9869610 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature