Ablation of CXCR4 expression in cardiomyocytes exacerbates isoproterenol‑induced cell death and heart failure.

ABSTRACT: CXCR4 is a seven‑transmembrane‑spanning Gi‑coupled receptor for the SDF‑1 chemokine and plays a critical role in cardiovascular development and post‑injury repair. However, the specific role of CXCR4 in cardiomyocytes is incompletely understood. It was hypothesized that CXCR4 activation in cardiomyocytes antagonizes β‑adrenoceptor/Gs signaling‑induced cardiac dysfunction. Cardiomyocyte‑specific CXCR4 knockout (CXCR4‑^CMKO) mice were generated by crossing CXCR4^fl/fl and MHC‑Cre^+/‑ mice. Their cardiac structure and function in the basal state are equivalent to that of the control MHC‑Cre^+/‑ littermates until at least 4 months old. However, following continuous subcutaneous administration of isoproterenol (Iso) via an osmotic mini‑pump, the ventricul

SUBMITTER: Cheng M 

PROVIDER: S-EPMC9869727 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature