Serum hormone levels and normal breast histology among premenopausal women.

ABSTRACT:

Purpose

Breast terminal duct lobular units (TDLUs) are the main source of breast cancer (BC) precursors. Higher serum concentrations of hormones and growth factors have been linked to increased TDLU numbers and to elevated BC risk, with variable effects by menopausal status. We assessed associations of circulating factors with breast histology among premenopausal women using artificial intelligence (AI) and preliminarily tested whether parity modifies associations.

Methods

Pathology AI analysis was performed on 316 digital images of H&E-stained sections of normal breast tissues from Komen Tissue Bank donors ages ≤ 45 years to assess 11 quantitative metrics. Associations of circulating factors with AI metrics were assessed using regression analyses, with inclusion of interact

SUBMITTER: Sherman ME 

PROVIDER: S-EPMC9869890 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature