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A survival tree based on stabilized score tests for high-dimensional covariates.

ABSTRACT: A survival tree can classify subjects into different survival prognostic groups. However, when data contains high-dimensional covariates, the two popular classification trees exhibit fatal drawbacks. The logrank tree is unstable and tends to have false nodes; the conditional inference tree is difficult to interpret the adjusted P-value for high-dimensional tests. Motivated by these problems, we propose a new survival tree based on the stabilized score tests. We propose a novel matrix-based algorithm in order to tests a number of nodes simultaneously via stabilized score tests. We propose a recursive partitioning algorithm to construct a survival tree and develop our original R package uni.survival.tree (https://cran.r-project.org/package=uni.survival.tree) for implementation. Simulations are performed to demonstrate the superiority of the proposed method over the existing methods. The lung cancer data analysis demonstrates the usefulness of the proposed method.

SUBMITTER: Emura T

PROVIDER: S-EPMC9870022 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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A survival tree based on stabilized score tests for high-dimensional covariates.

Emura Takeshi T Hsu Wei-Chern WC Chou Wen-Chi WC

Journal of applied statistics 20211021 2

A survival tree can classify subjects into different survival prognostic groups. However, when data contains high-dimensional covariates, the two popular classification trees exhibit fatal drawbacks. The logrank tree is unstable and tends to have false nodes; the conditional inference tree is difficult to interpret the adjusted <i>P</i>-value for high-dimensional tests. Motivated by these problems, we propose a new survival tree based on the stabilized score tests. We propose a novel matrix-base ...[more]

PMID: 36698545

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