Age-related and individual features of the HPA axis stress responsiveness under constant light in nonhuman primates.

ABSTRACT: The hypothalamic-pituitary-adrenal (HPA) axis is a key adaptive neuroendocrine system, dysfunction of which plays an important role in the increasing incidence of stress-dependent age-related pathology. Among the environmental factors effecting increase age-related diseases, great importance is given to disturbances of the light-dark schedule, particularly with increased illumination at night. While disruption of the light-dark schedule has long been recognized as a powerful behavioral stressor, little is known regarding stress reactivity of the HPA under constant light (CL) conditions, especially with aging and depending on the features of stress behavior. The purpose of this investigation was to study the age-related and individual features of the HPA axis response to acute stress exposu

SUBMITTER: Goncharova N 

PROVIDER: S-EPMC9870316 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature