Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only.

ABSTRACT:

Background

Screening for prostate cancer is burdened by a high rate of overdiagnosis. The most appropriate algorithm for population-based screening is unknown.

Methods

We invited 37,887 men who were 50 to 60 years of age to undergo regular prostate-specific antigen (PSA) screening. Participants with a PSA level of 3 ng per milliliter or higher underwent magnetic resonance imaging (MRI) of the prostate; one third of the participants were randomly assigned to a reference group that underwent systematic biopsy as well as targeted biopsy of suspicious lesions shown on MRI. The remaining participants were assigned to the experimental group and underwent MRI-targeted biopsy only. The primary outcome was clinically insignificant prostate cancer, defined as a Gleason score of 3+3. T

SUBMITTER: Hugosson J 

PROVIDER: S-EPMC9870590 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature