RIG-I-mediated innate immune signaling in tumors reduces the therapeutic effect of oncolytic vesicular stomatitis virus.

ABSTRACT:

Background

Oncolytic viral therapy is a promising method for tumor treatment. Currently, several oncolytic viruses (OVs) have been used as tumor therapy at different phases of research and clinical trials. OVs not only directly lyse tumor cells due to viral replication but also initiate host antitumor immune responses. Previous studies have primarily focused on how OVs activate adaptive immune responses in immune cells. However, the role of innate immune responses in tumors induced by OVs remains unclear.

Methods

To determine the innate immune responses induced by vesicular stomatitis virus (VSV), the mutant VSV^ΔM51 strain was used for the infection and quantitative polymerase chain reaction (qPCR) was employed to measure the transcriptional levels of antiviral ge

SUBMITTER: Zhang P 

PROVIDER: S-EPMC9870728 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature