Cytokine alterations during paraneoplastic neutrophilia and leukemoid reaction in patients with advanced melanoma.

ABSTRACT:

Background

Paraneoplastic leukemoid reaction (PLR) is a rare phenomenon in metastasized melanoma associated with poor prognosis and rapid disease progression. Currently, no specific therapeutic options exist other than treating the underlying malignancy.

Methods

Five cases of paraneoplastic neutrophilia in patients with advanced-stage IV melanoma were enrolled in our study. Cytokine concentrations in patients' serum samples were analyzed before and during PLR using a multiplex cytokine array. Further, immunohistochemical staining of tumor tissue biopsied during PLR was performed.

Results and conclusions

We observed a strong correlation between worsening of tumor burden and aggravation of neutrophilia. Cytokine measurements revealed an increase of proinflammatory cytok

SUBMITTER: Zhang XW 

PROVIDER: S-EPMC9870824 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature