Impact of body mass index and diabetes on myocardial fat content, interstitial fibrosis and function.

ABSTRACT:

Purpose

We hypothesize that both increased myocardial steatosis and interstitial fibrosis contributes to subclinical myocardial dysfunction in patients with increased body mass index and diabetes mellitus.

Background

Increased body weight and diabetes mellitus are both individually associated with a higher incidence of heart failure with preserved ejection fraction. However, it is unclear how increased myocardial steatosis and interstitial fibrosis interact to influence myocardial composition and function.

Methods

A total of 100 subjects (27 healthy lean volunteers, 21 healthy but overweight volunteers, and 52 asymptomatic overweight patients with diabetes) were prospectively recruited to measure left ventricular (LV) myocardial steatosis (LV-myoFat) and interstitial

SUBMITTER: Dong X 

PROVIDER: S-EPMC9870836 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature