Patient-reported geriatric assessment-based frailty index among older adults with gastrointestinal malignancies.

ABSTRACT:

Background

Older adults with cancer are at increased risk of treatment-related toxicities and excess mortality. We evaluated whether a patient-reported geriatric assessment (GA) based frailty index can identify those at risk of adverse outcomes.

Methods

Older adults (≥60 years) enrolled in a single-institutional prospective registry underwent patient-reported GA at initial evaluation in our medical oncology clinic. Using deficit accumulation method, we constructed a 44-item frailty index (CARE-FI), categorizing patients as robust, pre-frail, and frail. The primary outcome was overall survival (OS). Secondary outcomes included (a) functional decline at 3 months post-therapy (b) incident grade ≥3 treatment-related toxicities at six-month post-treatment. We used multivariate Co

SUBMITTER: Giri S 

PROVIDER: S-EPMC9870847 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature