Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial.

ABSTRACT: The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In addition to centralized randomization and blinding and large samples, SPAN aimed to introduce heterogeneity to simulate the heterogeneity embodied in clinical trials for robust conclusions. Here, we report the heterogeneity introduced by allowing the 6 SPAN laboratories to vary most of the biological and experimental model variables and the impact of this heterogeneity on middle cerebral artery occlusion (MCAo) performance. We included the modified intention-to-treat population of the control mouse cohort of the first SPAN trial (n=421) and examined the biological and procedural inde

SUBMITTER: Morais A 

PROVIDER: S-EPMC9870939 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature