Alveolar dead space fraction is not associated with early RV systolic dysfunction in pediatric ARDS.

ABSTRACT:

Primary hypothesis

We hypothesized that higher alveolar dead space fraction (AVDSf) at pediatric acute respiratory distress syndrome (PARDS) onset would be associated with right ventricular (RV) systolic dysfunction within the first 24 h of PARDS.

Study design and methods

We performed a retrospective single-center cohort study of PARDS patients with clinically obtained echocardiograms within 24 h. Primary exposure was AVDSf at PARDS onset. Primary outcome was RV systolic dysfunction as defined by RV global longitudinal strain (GLS) (>-18%). Secondary outcomes included pulmonary hypertension (PH) and RV systolic dysfunction as defined by other echocardiogram parameters, and measures of oxygenation. Unadjusted and adjusted logistic and linear regression were used to investigat

SUBMITTER: Chilcote D 

PROVIDER: S-EPMC9870940 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature