Neurophysiologic predictors of individual risk for post-operative delirium after elective surgery.

ABSTRACT:

Background

Post-surgical delirium is associated with increased morbidity, lasting cognitive decline, and loss of functional independence. Within a conceptual framework that delirium is triggered by stressors when vulnerabilities exist in cerebral connectivity and plasticity, we previously suggested that neurophysiologic measures might identify individuals at risk for post-surgical delirium. Here we demonstrate the feasibility of the approach and provide preliminary experimental evidence of the predictive value of such neurophysiologic measures for the risk of delirium in older persons undergoing elective surgery.

Methods

Electroencephalography (EEG) and transcranial magnetic stimulation (TMS) were collected from 23 patients prior to elective surgery. Resting-state EEG spectr

SUBMITTER: Ross JM 

PROVIDER: S-EPMC9870959 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature