β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila.

ABSTRACT: Germ cell development requires interplay between factors that balance cell fate and division. Early in their development, germ cells in many organisms divide mitotically with incomplete cytokinesis. Key regulatory events then lead to the specification of mature gametes, marked by the switch to a meiotic cell cycle program. Though the regulation of germ cell proliferation and meiosis are well understood, how these events are coordinated during development remains incompletely described. Originally characterized in their role as nucleo-cytoplasmic shuttling proteins, β-importins exhibit diverse functions during male and female gametogenesis. Here, we describe novel, distinct roles for the β-importin, Transportin-Serine/Arginine rich (Tnpo-SR), as a regulator of the mitosis to meiosis transit

SUBMITTER: Beachum AN 

PROVIDER: S-EPMC9870978 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature