Cyclin E overexpression in the Drosophila accessory gland induces tissue dysplasia.

ABSTRACT: The regulation of the cell division cycle is governed by a complex network of factors that together ensure that growing or proliferating cells maintain a stable genome. Defects in this system can lead to genomic instability that can affect tissue homeostasis and thus compromise human health. Variations in ploidy and cell heterogeneity are observed frequently in human cancers. Here, we examine the consequences of upregulating the cell cycle regulator Cyclin E in the Drosophila melanogaster male accessory gland. The accessory gland is the functional analog of the human prostate. This organ is composed of a postmitotic epithelium that is emerging as a powerful in vivo system for modelling different aspects of tumor initiation and progression. We show that Cyclin E upregulation i

SUBMITTER: Molano-Fernandez M 

PROVIDER: S-EPMC9871066 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature