Systemic Inflammation Causes Microglial Dysfunction With a Vascular AD phenotype.

ABSTRACT:

Background

Studies in rodents and humans have indicated that inflammation outside CNS (systemic inflammation) affects brain homeostasis contributing to neurodevelopmental disorders. Itis becoming increasingly evident that such early insults may also belinked to neurodegenerative diseases like late-onset Alzheimer's disease (AD). Importantly, lifestyle and stress, such as viral or bacterial infection causing chronic inflammation, may contribute to neurodegenerative dementia. Systemic inflammatory response triggers a cascade of neuroinflammatory responses, altering brain transcriptome, cell death characteristic of AD, and vascular dementia. Our study aimed to assess the temporal evolution of the pathological impact of systemic inflammation evoked by prenatal and early postnatal perip

SUBMITTER: Bathini P 

PROVIDER: S-EPMC9871075 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature