Towards accurate ¹⁷⁷Lu SPECT activity quantification and standardization using lesion-to-background voxel ratio.

ABSTRACT:

Background

Conventional calibration of the gamma camera consists of the calculation of calibration factors (CFs) (ratio of counts/cc and true concentration activity) as the function of the volume of interest (VOI). However, such method shows inconsistent results when the background activity varies. The aim of the present study was to propose a new calibration method by considering the sphere-to-background counts/voxel ratio (SBVR) in addition to the VOI for CFs calculation. A PET cylindrical flood phantom, a NEMA IQ body phantom, a Data spectrum Torso Phantom (ECT/TOR/P) and a LK-S Kyoto Liver/Kidney phantom were used. The NEMA IQ phantom was used to calibrate the camera and to produce CFs for the different spheres volumes and for varying sphere-to-background activity ratios. The s

SUBMITTER: Raskin S 

PROVIDER: S-EPMC9871126 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature