High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways.

ABSTRACT: Halogenated flame retardants comprising bisphenol A (BPA) derivatives, such as tetrabromobisphenol A (TBBPA), have been studied their adverse effects on human health. However, despite the fact that these halogenated BPAs are easily degraded in the environment, the risks to living organisms due to these degraded products have mostly been overlooked. To evaluate the potential toxicity of degraded TBBPAs and related compounds, we examined the cytotoxicity of halogenated bisphenol A derivatives possessing one to four halogen atoms in vitro. The results indicated that the degraded TBBPA derivatives exhibited strong cytotoxicity against HeLa cells than TBBPA. Interestingly, the di-halogenated BPA derivatives possessing two halogen atoms exhibited the strongest cytotoxicity among tested co

SUBMITTER: Suyama K 

PROVIDER: S-EPMC9871217 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature