Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis.

ABSTRACT: Secreted extracellular vesicles (EVs) are lipid bilayer particles without functional nucleus naturally released from cells which constitute an intercellular communication system. There is a broad spectrum of vesicles shed by cells based on their physical properties such as size (small EVs and large EVs), biogenesis, cargo and functions, which provide an increasingly heterogenous landscape. In addition, they are involved in multiple physiological and pathological processes. In cancer, EV release is opted by tumor cells as a beneficial process for tumor progression. Cutaneous melanoma is a cancer that originates from the melanocyte lineage and shows a favorable prognosis at early stages. However, when melanoma cells acquire invasive capacity, it constitutes the most aggressive and deadly ski

SUBMITTER: Benito-Martin A 

PROVIDER: S-EPMC9871288 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature