HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate.

ABSTRACT:

Background & aims

The intestinal epithelium intrinsically renews itself ex vivo via the proliferation of Lgr5⁺ intestinal stem cells, which is sustained by the establishment of an epithelial stem cell niche. Differentiated Paneth cells are the main source of epithelial-derived niche factor supplies and produce Wnt3 as an essential factor in supporting Lgr5⁺ stem cell activity in the absence of redundant mesenchymal Wnts. Maturation of Paneth cells depends on canonical Wnt signaling, but few transcriptional regulators have been identified to this end. The role of HNF4α in intestinal epithelial cell differentiation is considered redundant with its paralog HNF4γ. However, it is unclear whether HNF4α alone controls intrinsic intestinal epithelial cell growth and f

SUBMITTER: Jones C 

PROVIDER: S-EPMC9871320 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature