The effect of SGLT-2 inhibitors on cardiorespiratory fitness capacity: A systematic review and meta-analysis.

ABSTRACT: Objective: The study aimed to evaluate the effect of sodium-glucose transporter 2 (SGLT-2) inhibitors on various parameters of exercise capacity and provide an evidence-based basis for type 2 diabetes mellitus (T2DM) combined with heart failure (HF) patients or HF patients without T2DM who use SGLT-2 inhibitors to improve cardiorespiratory fitness (CRF). Methods: According to the participant, intervention, comparison, and outcome (PICO) elements, the effects of SGLT-2 inhibitor administration on VO₂ or VO₂peak were researched in this study. Weighted mean difference (WMD) and 95% confidence intervals (CIs) were calculated (random-effects model). Heterogeneity was assessed by the I² test. Results: Six studies were included according to th

SUBMITTER: Peng Y 

PROVIDER: S-EPMC9871354 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature