Patient genetics shape the autoimmune response in the blistering skin disease pemphigus vulgaris.

ABSTRACT:

Background and aim

Pemphigus vulgaris (PV) is known to have one of the strongest HLA associations among autoimmune diseases. DRB1*0402 and DQB1*0503 in particular are significantly overrepresented in PV patients in certain worldwide populations. Yet, there remain significant gaps in our understanding regarding the precise link between PV-associated HLA molecules, the specificity of the autoimmune response, and clinical expression. In this study we assessed correlations between factors including HLA genotype, ethnicity, autoantibody levels, and lesion distribution in a cohort of 293 patients.

Methods and population

Participants were recruited from multiple outpatient dermatology clinic settings and patient support meetings in the USA. On intake, patients provided venous blood

SUBMITTER: Baker J 

PROVIDER: S-EPMC9871500 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature