SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke.

ABSTRACT:

Background and purpose

Acute ischemic stroke (AIS) is a fearful complication of Coronavirus Disease-2019 (COVID-19). Aims of this study were to compare clinical/radiological characteristics, endothelial and coagulation dysfunction between acute ischemic stroke (AIS) patients with and without COVID-19 and to investigate if and how the SARS-CoV-2 spike protein (SP) was implicated in triggering platelet activation.

Methods

We enrolled AIS patients with COVID-19 within 12 h from onset and compared them with an age- and sex-matched cohort of AIS controls without COVID-19. Neuroimaging studies were performed within 24 h. Blood samples were collected in a subset of 10 patients.

Results

Of 39 AIS patients, 22 had COVID-19 and 17 did not. Admission levels of Factor VIII and vo

SUBMITTER: De Michele M 

PROVIDER: S-EPMC9871539 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature